Publications by authors named "G Sanchez-Delgado"
Declines in physical and cognitive function are common in older adults. The circulating enzyme glycosylphosphatidylinositol (GPI)-specific phospholipase D1 (GPLD1) is elevated after exercise and has been associated with improved cognitive function when administered to aged mice. The purpose of this study was to investigate the relationship between GPLD1 and both cognitive function and brain structure/function in older adults with either high or low levels of physical activity.
View Article and Find Full Text PDFThe constrained energy model posits that the increased total daily energy expenditure (TDEE) in response to exercise is often less than the energy cost of the exercise prescribed. The mechanisms behind this phenomenon, coined "exercise-related energy compensation" (ExEC), are poorly understood, and it is unknown if ExEC is coupled with metabolic adaptation. Using a randomized controlled 24-week exercise intervention, individuals who demonstrated ExEC were identified.
View Article and Find Full Text PDFHumans require energy to sustain their daily activities throughout their lives. This narrative review aims to () summarize principles and methods for studying human energy expenditure, () discuss the main determinants of energy expenditure, and () discuss the changes in energy expenditure throughout the human life course. Total daily energy expenditure is mainly composed of resting energy expenditure, physical activity energy expenditure, and the thermic effect of food.
View Article and Find Full Text PDFArticle Synopsis
- Cold exposure can make a special type of fat in our body called brown adipose tissue (BAT) work better, which may help improve heart and metabolism health.
- When young adults are in a cold environment for 2 hours, their bodies produce different types of fat signals, but people who are overweight don't show as much change as those at a healthier weight.
- The changes in fat signals from the cold are linked to good things like lower fat and sugar levels in the body, but exercising for 24 weeks doesn't change how the body reacts to cold.
Objective: The study objective was to investigate the effect of cold exposure on the plasma levels of five potential human brown adipokines (chemokine ligand 14 [CXCL14], growth differentiation factor 15 [GDF15], fibroblast growth factor 21 [FGF21], interleukin 6 [IL6], and bone morphogenic protein 8b [BMP8b]) and to study whether such cold-induced effects are related to brown adipose tissue (BAT) volume, activity, or radiodensity in young humans.
Methods: Plasma levels of brown adipokines were measured before and 1 h and 2 h after starting an individualized cold exposure in 30 young adults (60% women, 21.9 ± 2.