Optical coherence tomography as an adjunct tool to assess response to treatment in cerebral venous thrombosis: A prospective longitudinal study.

Introduction: Papilledema, due to raised intracranial pressure (ICP) is commonly seen in cerebral venous thrombosis (CVT) and can have serious complications. This study reports the quantitative assessment of papilledema through the measurement of the Peripapillary choroidal thickness (ChT) and Peripapillary retinal nerve fiber layer thickness (RNFLT) using optical coherence tomography (OCT).

Methods: We conducted a prospective longitudinal study of 30 subjects with CVT.

Effect of intraperitoneal magnesium sulfate in the prevention of postoperative pain in daycare laparoscopic cholecystectomy - A prospective randomized controlled trial.

This study evaluated the efficacy of intraperitoneal magnesium sulfate (MgSO) in preventing postoperative pain after elective laparoscopic cholecystectomy (LC). It is a prospective, double-blinded, placebo-controlled, randomized trial which included 64 patients who underwent LC. Patients were equally randomized into Groups A and B.

Formulation development and evaluation of zolmitriptan oral soluble films using 2 factorial designs.

Objective: The present investigation involves the development of zolmitriptan oral soluble film (OSF) formulations and optimization with quality by design (QBD) using natural polymers and evaluation.

Materials And Methods: Initially, various natural polymers such as sodium alginate, pectin, and gelatin were screened by casting films using solvent casting technique and the prepared films were evaluated. Based on the physical and mechanical properties, sodium alginate was selected as best film former and zolmitriptan-loaded films were casted.

Synthesis and biological evaluation of phaitanthrin congeners as anti-mycobacterial agents.

Natural alkaloid, tryptanthrin (indolo[2,1-b]quinazoline-6,12-dione) and its analogues are found to exhibit potent anti-tubercular activity against MDR-TB. A novel class of indolo[2,1-b]quinazolinones have been synthesized to evaluate their anti-mycobacterial activity. Enoyl-acyl carrier protein reductase (InhA) of Mycobacterium tuberculosis is one of the key enzymes and has been validated as an effective anti-microbial target.