Publications by authors named "G Sahni"
Introduction: Second-generation androgen receptor axis-targeting (ARAT) agents have become a standard treatment for patients with advanced prostate cancer (PC), however much remains unknown about the potential cardiovascular toxicities.
Patients And Methods: We performed a systematic search of PubMed, Embase, Web of Science, and Cochrane library for randomized controlled trials of patients receiving ARAT agents for PC from inception to March 2023. The odds ratios (ORs) of all-grade and high-grade cardiovascular adverse events (CVAEs) for patients treated with and without ARAT agents were pooled for meta-analysis.
Autism is a complex neurodevelopmental disorder which disrupts communication, social and interactive skills followed by appearance of repetitive behavior. The underlying etiology remains incomprehensible but genetic and environmental factors play a key role. Accumulated evidence shows that alteration in level of gut microbes and their metabolites are not only linked to gastrointestinal problems but also to autism.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the impact of immune checkpoint inhibitor (ICI) myocarditis on global circumferential strain (GCS) and global radial strain (GRS), which are measures of heart function, comparing 75 ICI myocarditis patients to 50 controls without myocarditis.
- Pre-treatment GCS and GRS were similar in both groups, but those with myocarditis had significantly lower GCS and GRS during treatment.
- Lower GCS and GRS correlated with a higher risk of cardiovascular events, indicating their potential as better indicators of heart health compared to traditional markers like cardiac troponin T and left ventricular ejection fraction.