Effectiveness and Current Status of Icariin in the Treatment of Rotator Cuff Injury Associated with Osteoporosis.

Rotator cuff injury is a disease in which the muscle and tendon that constitute the rotator cuff are torn causing shoulder pain and limited function. Osteoporosis (OP) is a systemic metabolic bone disease characterized by decreased bone mass, destruction of bone microstructure, decreased bone strength, and increased bone fragility. Both are common musculoskeletal diseases that occur in middle-aged and elderly people, and their prevalence gradually increases with age.

Experimental investigation and molecular dynamics simulation for the effect of a novel Gemini cationic surfactant on gas coal wettability.

Water-injected fracturing fluids can wet the coal body and reduce the amount of dust produced during coal mining. In order to enhance the wetting performance of fracturing fluids, a Gemini cationic surfactant named Gemini-TOH was innovatively synthesized in this paper using a three-step process. On this basis, a Gemini-TOH/KCl composite fracturing fluid system was developed by adding KCl.

Revealing the removal behavior of five neglected microplastics in coagulation-ultrafiltration processes: Insights from experiments and predictive modeling.

Typical water treatment processes are essential for mitigating the risk of microplastic contamination in drinking water. The integration of experiments and machine learning offers a promising avenue to elucidate microplastic removal behavior, yet relevant studies are scarce. To address this gap, this study combined experimental and artificial neural network (ANN) modeling to explore the removal behavior and mechanisms of five neglected microplastics in typical coagulation-ultrafiltration processes.

Recent advances in targeted degradation in the RAS pathway.

(rat sarcoma) is one of the most frequently mutated gene families in cancer, encoding proteins classified as small GTPases. Mutations in RAS proteins result in abnormal activation of the RAS signaling pathway, a key driver in the initiation and progression of various malignancies. Consequently, targeting RAS proteins and the RAS signaling pathway has become a critical strategy in anticancer therapy.