Publications by authors named "G S Vogt"

Loss-of-function variants in ATP6V0A2, encoding the trans Golgi V-ATPase subunit V0a2, cause wrinkly skin syndrome (WSS), a connective tissue disorder with glycosylation defects and aberrant cortical neuron migration. We used knock-out (Atp6v0a2) and knock-in (Atp6v0a2) mice harboring the R755Q missense mutation selectively abolishing V0a2-mediated proton transport to investigate the WSS pathomechanism. Homozygous mutants from both strains displayed a reduction of growth, dermis thickness, and elastic fiber formation compatible with WSS.

View Article and Find Full Text PDF

Bacterial resistance to antibiotics is a rapidly increasing threat to human health. New strategies to combat resistant organisms are desperately needed. One potential avenue is targeting two-component systems, which are the main bacterial signal transduction pathways used to regulate development, metabolism, virulence, and antibiotic resistance.

View Article and Find Full Text PDF
Article Synopsis
  • Commensal anaerobic bacteria can have similar levels to harmful pathogens in chronic respiratory infections, influencing how pathogens behave by competing for resources and producing toxic byproducts.
  • The study highlights how short chain fatty acids (SCFAs) like propionate and butyrate disrupt important fatty acid metabolism, leading to reduced bacterial growth and higher sensitivity to antibiotics.
  • These metabolic changes suggest that the composition of the airway microbiome, along with the metabolites they generate, can directly affect which pathogens thrive, indicating that combining SCFAs with traditional antibiotics could enhance treatment effectiveness.
View Article and Find Full Text PDF

Background: In this multicenter study, performance of a novel continuous glucose monitoring (CGM) system was evaluated.

Methods: Adult participants with diabetes were included in the study. They each wore three sensors of the CGM system on the upper arms for up to 14 days.

View Article and Find Full Text PDF

The biology of extinct animals is usually reconstructed from external morphological characters and comparison with present-day analogues. Internal soft organs are very rarely preserved in fossils and require high-tech approaches for visualization. Here, we report the internal anatomy of a female and male of the ~ 162 Myr-old lobster Eryma ventrosum from the Jurassic La Voulte-sur-Rhône Konservat-Lagerstätte in France using X-ray synchrotron tomography.

View Article and Find Full Text PDF