Renal limited sarcoidosis presenting with acute kidney injury.

Sarcoidosis is a multisystem granulomatous disease of unknown etiology, characterized by noncaseating epithelioid granuloma, multinucleate giant cells, and tissue destruction. While lung and lymph node involvement is common, isolated renal involvement is rare. We report the case of a 55-year-old female patient, with renal limited sarcoidosis, who presented with worsening sensorium and acute kidney injury.

The effect of a provisional diagnosis on intern diagnostic reasoning: a mixed methods study.

Objectives: Competency in diagnostic reasoning is integral to medical training and patient safety. Situativity theory highlights the importance of contextual factors on learning and performance, such as being informed of a provisional diagnosis prior to a patient encounter. This study aims to determine how being informed of a provisional diagnosis affects an intern's approach to diagnostic reasoning.

Trauma Causing Complications After Cleft Lip Repair.

A case series of early postoperative complications due to trauma following primary cleft lip repair has been presented. Out of 193 primary cleft lip repair performed over the past 4 years, 5 patients had trauma related complications, 2 had complete wound dehiscence, 2 had partial dehiscence, and 1 presented with bleeding. This is the first report on complications following trauma after cleft lip repair.

A bibliometric analysis of studies on environmental enrichment spanning 1967-2024: patterns and trends over the years.

Environmental Enrichment (EE) has received considerable attention for its potential to enhance cognitive and neurobiological outcomes in animal models. This bibliometric analysis offers a comprehensive evaluation of the EE research spanning from 1967 to 2024, utilizing data extracted from Scopus and analyzed through R and VOSviewer. The volume of publications, citation patterns, and collaborations were systematically reviewed, highlighting important contributions and emerging trends within the field of animal research.

Unveiling the potential of gene editing techniques in revolutionizing Cancer treatment: A comprehensive overview.

Gene editing techniques have emerged as powerful tools in biomedical research, offering precise manipulation of genetic material with the potential to revolutionize cancer treatment strategies. This review provides a comprehensive overview of the current landscape of gene editing technologies, including CRISPR-Cas systems, base editing, prime editing, and synthetic gene circuits, highlighting their applications and potential in cancer therapy. It discusses the mechanisms, advantages, and limitations of each gene editing approach, emphasizing their transformative impact on targeting oncogenes, tumor suppressor genes, and drug resistance mechanisms in various cancer types.