Lawsonia inermis-organically modified chitosan intercalated bentonite clay: A multifunctional nanotheranostic system for controlled drug delivery, sensing and cellular imaging.

This study presents the development of organo-bentonites (OBs); a cost-effective drug delivery system holding both sensing and imaging capabilities. The OBs were synthesized using quaternary ammonium cations derived from chitosan, Lawsonia inermis, and pyrene/anthracene carboxaldehyde combinations through a three-step process: Mannich reaction, quaternization, and intercalation. Physicochemical characterization confirms the organic modification of bentonite.

Multifunctional chitosan ferrogels for targeted cancer therapy by on-demand magnetically triggered drug delivery and hyperthermia.

A facile method for the synthesis of chitosan ferrogels for magnetically triggered drug release and hyperthermia treatment is presented. The glyoxal crosslinked, dried ferrogels (magnetic bioaerogels) have been characterized by FTIR, XRD, TGA and VSM analyses and they possess unique characteristics such as high porosity, ultra-low density and superparamagnetism (M up to 56 emu g). In addition, they present high drug (Doxorubicin, DOX) loading efficiency (~40 %), tumor-specific pH-responsive swelling, excellent biodegradation, remotely switchable drug release and high magnetic hyperthermia potential (42 °C within 4 min).

Injectable polyelectrolyte complex-nascent HAP biodegradable antibiotic delivery system for the treatment of osteomyelitis.

An injectable osteoconductive polyelectrolyte complex (PEC)-hydroxyapatite (HAP) formulation capable of controlled delivery of ciprofloxacin has been developed from a novel biodegradable PEC and antibiotic loaded nascent hydroxyapatite (n-HAP) for the treatment of osteomyelitis. A single source (chitosan) derived polyelectrolytes were complexedin the presence of n-HAP, pre-loaded with ciprofloxacin. The PEC-(n-HAP) nanoformulation (HPEC) was characterized by FT-IR, XRD, TGA and TEM analyses.

Intrinsically radiopaque and antimicrobial cellulose based surgical sutures from mechanically powerful plant leaf fibers.

The judicious configuration of a flexible radiopaque suture would be exemplary to facilitate effortless tracking and precise diagnosis of the sutured surgical site by various X-ray assisted imaging modalities and simultaneously serve as a complementary tool for monitoring the fate of the suture material during the post-operative course. A unique radiopaque cellulose based surgical suture (RF) with good mechanical properties was developed by strategically controlled mercerization and bleaching of mechanically strong natural cellulosic fibers extracted from plant leaves followed by the facile dip-coating of SrO integrated polylactic acid (PLA). RF exhibited admirable straight-pull tensile strength (184 MPa) and commendable contrast enhancement (277.

Intrinsically radiopaque biomaterial assortments: a short review on the physical principles, X-ray imageability, and state-of-the-art developments.

X-ray attenuation ability, otherwise known as radiopacity of a material, could be indisputably tagged as the central and decisive parameter that produces contrast in an X-ray image. Radiopaque biomaterials are vital in the healthcare sector that helps clinicians to track them unambiguously during pre and post interventional radiological procedures. Medical imaging is one of the most powerful resources in the diagnostic sector that aids improved treatment outcomes for patients.