Publications by authors named "G S Pinkus"
Lymphocytic lobulitis (LL) is characterized by prominent lymphocytic infiltrates centered on lobules. Sclerosing lymphocytic lobulitis (SCLL) associated with diabetes mellitus (DM) or autoimmune disease (AI) was the first type to be described. Subsequently, non-sclerosing LL (NSCLL) was reported as an incidental finding in prophylactic mastectomies due to high risk germline mutations or a family history of breast cancer.
View Article and Find Full Text PDFCutaneous Manifestations of Myeloid Neoplasms Exhibit Broad and Divergent Morphologic and Immunophenotypic Features but Share Ancestral Clonal Mutations With Bone Marrow.
Mod Pathol
January 2024
Article Synopsis
- - The study analyzed skin and blood/bone marrow samples from 17 patients with various cutaneous neoplasms, primarily focusing on cutaneous acute myeloid leukemia (c-AML) and different types of dendritic cell neoplasms.
- - A significant finding was that many c-AML patients had shared clonal mutations between their skin and bone marrow, with 70% also showing mutations like NPM1 and KMT2A rearrangements.
- - The results indicate that cutaneous and myeloid neoplasms share common genetic mutations, enhancing the understanding of the relationship between these skin manifestations and underlying blood disorders.
Background: Programmed cell death ligand 1 (PD-L1) expression on tumor cells engages the PD-1 receptor on T cells, inhibiting anti-tumor responses. PD-L1 has been detected in cases of post-transplant lymphoproliferative disorder (PTLD) but reports are limited. Here we examine PD-L1 expression and evaluate for clinical correlations.
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