Caspase-1/11 controls Zika virus replication in astrocytes by inhibiting glycolytic metabolism.

Zika virus (ZIKV) poses a significant threat due to its association with severe neurological complications, particularly during pregnancy. Although viruses exhibit tropism for neural cells, including astrocytes, the role of these cells in controlling ZIKV replication remains unclear. In this study, we demonstrated that ZIKV induces caspase-1 activation in primary astrocytes despite the absence of classical signs of inflammasome activation.

Quantifying the enzootic leukosis virus threat: how prevalent is the natural infection in Crioulo Lageano cattle in southern Brazil?

Enzootic Bovine Leukosis (EBL), is infectious disease affecting especially older animals, although animals of all ages can be infected with the Bovine Leukemia Virus (BLV). Crioula Lageana is a locally adapted, rustic and long-lived bovine breed, important as a genetic resource. However, little is known about its health status, making it difficult to preserve the breed.

Clinical validation of an artificial intelligence algorithm for classifying tuberculosis and pulmonary findings in chest radiographs.

Background: Chest X-ray (CXR) interpretation is critical in diagnosing various lung diseases. However, physicians, not specialists, are often the first ones to read them, frequently facing challenges in accurate interpretation. Artificial Intelligence (AI) algorithms could be of great help, but using real-world data is crucial to ensure their effectiveness in diverse healthcare settings.

Periodic breathing during exercise in heart failure: beyond the classic risk factors.

Periodic breathing is a peculiar ventilatory pattern in patients with heart failure (HF), characterized by cyclic oscillations in minute ventilation. This phenomenon has been observed in awake patients, during sleep, and during exercise. Periodic breathing during exercise, also known as exercise oscillatory ventilation (EOV), is an important marker of clinical and functional status, morbidity, and mortality in HF patients.

Sotorasib resistance triggers epithelial-mesenchymal transition and activates AKT and P38-mediated signaling.

Background: The molecular non-genetic changes of resistance to sotorasib are currently uncertain. The aim of this study was to generate a sotorasib-resistant cell line via selective pressure and systematically examine the molecular and phenotypic alterations caused by resistance.

Methods: Mutant NCI-H358 (KRAS) were exposed to incremental doses (2-512 nM) of sotorasib.