Microbial community interactions on a chip.

Multispecies microbial communities drive most ecosystems on Earth. Chemical and biological interactions within these communities can affect the survival of individual members and the entire community. However, the prohibitively high number of possible interactions within a microbial community has made the characterization of factors that influence community development challenging.

Transparent porous films with real refractive index close to unity for photonic applications.

Herein, we demonstrate mechanically stable large-area thin films with a purely real refractive index () close to 1 in the optical range. At specific wavelengths, it can reach values as small as = 1.02, the lowest reported for thin solid slabs.

Inhibition of ULK1/2 and KRAS controls tumor growth in preclinical models of lung cancer.

Mutational activation of occurs commonly in lung carcinogenesis and, with the recent U.S. Food and Drug Administration approval of covalent inhibitors of KRAS such as sotorasib or adagrasib, KRAS oncoproteins are important pharmacological targets in non-small cell lung cancer (NSCLC).

Trap Depth Distribution Determines Afterglow Kinetics: A Local Model Applied to ZnGaO:Cr.

Persistent luminescence materials have applications in diverse fields such as smart signaling, anticounterfeiting, and in vivo imaging. However, the lack of a thorough understanding of the precise mechanisms that govern persistent luminescence makes it difficult to develop ways to optimize it. Here we present an accurate model to describe the various processes that determine persistent luminescence in ZnGaO:Cr, a workhorse material in the field.

p53R172H and p53R245W Hotspot Mutations Drive Distinct Transcriptomes in Mouse Mammary Tumors Through a Convergent Transcriptional Mediator.

Unlabelled: Aggressive breast cancers harbor TP53 missense mutations. Tumor cells with TP53 missense mutations exhibit enhanced growth and survival through transcriptional rewiring. To delineate how TP53 mutations in breast cancer contribute to tumorigenesis and progression in vivo, we created a somatic mouse model driven by mammary epithelial cell-specific expression of Trp53 mutations.