The immunotropic activity of three derivatives of docosahexaenic acid (N-docosahexaenoyl-L-serine phosphate, N-docosahexaenoyl-L-threonine phosphate, and N-docosahexaenoyl-L-tyrosine phosphate) in complexes with high-purity human alpha-fetoprotein was evaluated. The polyene compounds stimulate the humoral immunity in mice immunized with T-dependent antigen (ram red blood cells). The immunotropic activity of the alpha-fetoprotein-ligand complexes studied depends on the structure and the content of polyene ligands.
View Article and Find Full Text PDFEksp Klin Farmakol
October 2000
The immunopharmacological properties of two new compounds with an 8-azasteroidal structure, representing the salts (hydrochloride and acetate) of 12-imino-substituted 8-aza-D-homogonan, were studied in comparison with the properties of the immunostimulant trimeson. Similar to trimeson, both new compounds produce a dose-dependent activation of the humoral chain of immunogenesis in the model of primary immune response to goat erythrocytes in CBA, C57BL/6, and C57W mice. The immunostimulant activity of the 8-aza-D-homogonan derivatives is inversely proportional to the antigen load (2 x 10(7)-2 x 10(9) goat erythrocytes per mice) and depends to a considerable extent of the genotype of experimental animals.
View Article and Find Full Text PDFThe effect of the immunostimulator trimeson of the 8-aza-gomogonan series on the cells of the mononuclear monocyte system was studied in C3H and ICR mice in vitro. Intraperitoneal injection of trimeson (50 mg/kg 1 x 10(-7)-1 x 10(6) M) inhibits, as a rule, the initial stages of the phagocytizing process but stimulates the bactericidal properties of the peritoneal phagocytes and their mechanisms of processing and destruction of the antigen material. In the system of adaptive transfer of donor splenocytes and peritoneal macrophages to recipients exposed to lethal radiation, trimeson (20 mg/kg intravenously, 50 mg/kg per os) increases the immunogenic function of the mononuclear phagocytes in formation of the primary immune response to sheep erythrocytes.
View Article and Find Full Text PDFIt was shown in mice experiments that intragastric administration of the low-molecular synthetic immunomodulator of the 8-azasteroid series trimesone increases the immune response of humoral and cell-mediated types to the thymus-dependent antigen, the sheep erythrocytes. The stimulating effect of the drug in vivo is determined by the dose, the antigen load, and the animals' genotype and does not yield to the effect of levamisole or exceeds it in identical experimental conditions.
View Article and Find Full Text PDFThe influence of various concentrations (10(-9) - 10(-6) M) of the new immunostimulator trimezon of 8-aza-D-homogonan range upon in vitro proliferation of human lymphocytes, stimulated by PHA 0.5-10.0 micrograms/ml), was investigated by 3H-thymidine incorporation analysis.
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