[Clinic and functional features of chronic obstructive pulmonary disease after virus-induced acute exacerbations.].

Aim: To establish symptoms, lung function and to evaluate subsequent exacerbations of chronic obstructive pulmonary disease (COPD) during a year after virus-induced COPD exacerbations.

Materials And Methods: Patients hospitalized with viral (=60), bacterial (=60) and viral-bacterial (=60) COPD exacerbations were enrolled to single-center prospective observational study. COPD was diagnosed according spirography criteria.

Network analysis reveals a role of the hippocampus in absence seizures: The effects of a cannabinoid agonist.

The role of the hippocampus (Hp) in absence epileptic networks and the effect of endocannabinoid system on this network remain enigmatic. Here, using adapted nonlinear Granger causality, we compared the differences in network strength in four intervals (baseline or interictal, preictal, ictal and postictal) in two hours before (Epoch 1) and six hours (epochs 2, 3 and 4) after the administration of three different doses of the endocannabinoid agonist WIN55,212-2 (WIN) or solvent. Local field potentials were recorded for eight hours in 23 WAG/Rij rats in the Frontal (FC), Parietal PC), Occipital Cortex (OC) and in the hippocampus (Hp).

[Organization of forensic medical service work in case of fires with massive number of victims].

A complex algorithm is proposed for the forensic medical service response in emergency situations marked by a large number of deaths from fire. Its use will promote increased efficiency in the work of forensic medical units while limiting the consequences to human victims in emergency situations.

[Comparative analysis of post-translational modifications in plasma proteome of patients with cerebral ischemia based on HPLC-MS/MS method].

The relative differences between post-translational modifications (PTM) of proteins in blood plasma samples of patients with cerebral ischemia (CI) and healthy people were investigated using of the method of label-free comparative proteomic analysis based on the technology of tandem HPLC-MS/MS. For PTM detection we used multiple MS/MS search in the database Mascot for variable PTM and Progenesis LS-MS software. In the CI plasma samples, we observed an increase in the proportion of peptides with such PTM as phosphorylation of serine, threonine, and tyrosine, acetylation of lysine and protein N-term, ubiquitination of lysine and deamidation of glutamine related to clinically significant processes were revealed.