[Biological functions and therapeutic properties of angiogenins].

The review is devoted to an analysis of recently published data on the biological functions of angiogenins with a view to their potential use as an active basis for new pharmaceuticals and cosmetics.

Distribution and elimination of milk angiogenin in mouse immunocompetent organs and brain.

Dynamics of angiogenin content in the serum, thymus, bone marrow, and brain of mice was studied after intravenous injection. The maximum angiogenin retention was detected in the thymus, while high rate of its elimination in the brain.

Stabilizing effect of milk angiogenin on the crystal structure of biological fluids.

We revealed a new property of angiogenin to restore the crystal structure of biological fluids (human blood plasma and exudates) impaired in various pathologies.

Cow milk angiogenin induces cytokine production in human blood leukocytes.

Angiogenin isolated from cow milk induces the production of cytokines IL-1beta, IL-6, and TNF-alpha in human leukocytes; the level of production of each cytokine depends on the concentration of the preparation, and the dynamics of production depends on the time from the beginning of induction. Simultaneous treatment with angiogenin and phytohemagglutinin had an additive effect on the production of cytokines, the time of this effect manifestation being individual for each cytokine.

[Milk angiogenin (Review)].

Recent data on angiogenin, a multifunctional member of pancreatic RNase protein superfamily, are summarized. Advances in the investigation of angiogenin structure, function, and properties are analyzed. Potentialities in natural angiogenin production from inexpensive dairy by-products are demonstrated.