Publications by authors named "G S Keyes"
Article Synopsis
- The study explores the accumulation of hyperphosphorylated Tau (pTau) and other ApoER2-Dab1 pathway components in specific neuron populations in sporadic Alzheimer's disease (sAD), highlighting their role in early disease progression.
- Researchers found that key components of the ApoER2-Dab1 signaling pathway are highly present in neurons affected by pTau and correlate with cognitive decline in mild cognitive impairment (MCI) and sAD stages.
- The findings suggest that disruptions in the ApoER2-Dab1 pathway contribute to the development of pTau pathology and other associated cellular abnormalities in the early phases of sAD, supporting a broader understanding of disease mechanisms.
Article Synopsis
- Sporadic Alzheimer's disease (sAD) is characterized by selective neurodegeneration in specific brain regions, which the authors suggest is influenced by local disruptions in ApoER2-Dab1 signaling rather than the traditional prion-like Tau spread model.
- The study used various methods to investigate the expression of ApoER2 and components of the RAAAD-P-LTP pathway in neurons, particularly in areas affected by early Tau pathology.
- Findings indicate that neurons vulnerable to degeneration express high levels of ApoER2 and show accumulation of RAAAD-P-LTP components, which are linked to cognitive deficits and the progression of sAD.
Article Synopsis
- - The study proposes a new model for sporadic Alzheimer's disease (sAD) that focuses on local Tau hyperphosphorylation due to disrupted ApoER2-Dab1 signaling, suggesting that this disruption makes specific neurons more vulnerable to degeneration rather than attributing the condition to widespread brain changes.
- - Researchers conducted experiments on 64 autopsied cases, using hybridization and immunohistochemistry to analyze ApoER2 expression and the presence of various components related to the Reelin/ApoE/ApoJ-ApoER2-Dab1-P85α-LIMK1-Tau-PSD95 (RAAAD-P-LTP) pathway in regions affected by early Tau pathology.
- - Their findings confirmed that neurons likely
Psoriasis is characterized by intense pruritus, with a subset of individuals with psoriasis experiencing thermal hypersensitivity. However, the pathophysiology of thermal hypersensitivity in psoriasis and other skin conditions remains enigmatic. Linoleic acid is an omega-6 fatty acid that is concentrated in the skin, and oxidation of linoleic acid into metabolites with multiple hydroxyl and epoxide functional groups has been shown to play a role in skin barrier function.
View Article and Find Full Text PDFBiochemical and behavioral effects of decreasing dietary linoleic acid and increasing eicosapentaenoic acid and docosahexaenoic acid in a rat chronic monoarthrits model.
Prostaglandins Leukot Essent Fatty Acids
December 2022
Clinical studies have demonstrated that decreasing linoleic acid (LA) while increasing eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in diets evokes an analgesic effect in headache sufferers. We utilized a rat chronic monoarthritis model to determine if these analgesic effects can be reproduced in rats and to and further probe potential analgesic mechanisms. We fed 8 rats a control diet (with fatty acid levels similar to standard US diets) and 8 rats a low LA diet with added EPA and DHA (H3L6 diet) and after 10 weeks, performed a unilateral intraarticular injection of Complete's Freund Adjuvant (CFA).
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