[Extragenital diseases, comorbidities, and polymorbidity in maternal death].

Objective: To study the structure and significance of comorbidities and polymorbidity in maternal death.

Material And Methods: Sixty-five autopsy protocols of maternal deaths in the Novosibirsk Region in the period of 1994 to 2018 were analyzed.

Results: Extragenital diseases are the leading diseases in the nosological structure in maternal mortality.

[Activity of alanine- and aspartate-aminotransferases in organs of albino rats subjected to whole body gamma-irradiation and physical exercise].

The investigations of enzyme activity such as aspartate aminotransferase (AST, KE 2.6.1.

Standardization and management of orthopedic implants.

Because the price of orthopedic implants has soared to astronomical heights, and insurance companies are paying less for surgical procedures, institutions must find ways of decreasing their costs and reducing their overhead. In the operating room the orthopedic nurse manager can be instrumental in reducing the amount of implant inventory by collecting and reporting data concerning shelf life of implants and coordinating new product trials and evaluation periods to decrease the number of implant systems to one or two.

[Effect of repeated injections of GABA on the GABA shunt and various associated reactions in the rat brain].

Effect of repeated administrations of gamma-amino butyric acid (GABA) at doses corresponding to those which are used in clinical medicine, on the state of GABA-shunt and intensity of alpha-ketoglutarate dehydrogenase and aminotransferase reactions as well as on the level of GABA and glutamate was studied in cerebellum, cortex and trunkus cerebri of rat brain. Administration of GABA (5 injections at a dose of 5 mg/kg) caused distinct alterations in central nervous system, which involved activation of GABA-transaminase, utilizing GABA, and inactivation of glutamate decarboxylase, producing the amine, as well as a decrease of GABA and glutamate levels and an increase in alpha-ketoglutarate utilization and activation of aminotransferase reactions. These alterations were especially distinct in cerebellum, where initial high intensity of GABA shunt functioning and minimal level of GABA were observed.

[The use of pyridoxal-5-phosphate in determining aminotransferase activity in brain tissue].

When aspartate- and alanine transaminase (AST and ALT, respectively) activities were studied in homogenates of rat cerebellum, brain cortex and brain stem (using a modified procedure by Raitman and Frenkel), addition of 50 microM pyridoxal-5-phosphate (PALP) increased 2-3-fold the activity studied. With an increase in PALP concentration from 6.25 microM up to 200 microM AST- and ALT-activities increased dose-dependently, while at 100-200 microM concentration of PALP saturation of the reaction occurred and 200 microM of PALP decreased the AST activity.