Unveiling the Anti-Angiogenic Potential of Small-Molecule (Kinase) Inhibitors for Application in Rheumatoid Arthritis.

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation leading to joint damage and systemic complications. Angiogenesis promotes inflammation and contributes to RA progression. This study evaluated potential anti-angiogenic effects of several compounds including small-molecule kinase inhibitors, such as sunitinib (pan-kinase inhibitor), tofacitinib (JAK-inhibitor), NIKi (NF-κB-inducing kinase inhibitor), and the integrin-targeting peptide fluciclatide, using a scratch assay and 3D spheroid-based models of angiogenesis.

Fungal Planet description sheets: 1697-1780.

Novel species of fungi described in this study include those from various countries as follows: , from accumulated snow sediment sample. , on leaf spots of . , on submerged decaying wood in sea water, on , as endophyte from healthy leaves of .

The performance of a lateral flow SARS-CoV-2 antibody assay and semi-autonomous SARS-CoV-2 antisense and sense RNA fluorescence in situ hybridization assay in a prospective cohort pilot study within a Dutch military population.

At the beginning of the COVID-19 pandemic, diagnostic testing was not accessible for mildly ill or asymptomatic individuals. Military operational circumstances exclude the usage of reference laboratory tests. For that reason, at the beginning of the pandemic alternative test methods were needed in order to gain insight into the SARS-CoV-2 status of military personnel.

Inferring gene regulatory networks of ALS from blood transcriptome profiles.

One of the most robust approaches to the prediction of causal driver genes of complex diseases is to apply reverse engineering methods to infer a gene regulatory network (GRN) from gene expression profiles (GEPs). In this work, we analysed 794 GEPs of 1117 human whole-blood samples from Amyotrophic Lateral Sclerosis (ALS) patients and healthy subjects reported in the GSE112681 dataset. GRNs for ALS and healthy individuals were reconstructed by ARACNe-AP (Algorithm for the Reconstruction of Accurate Cellular Networks - Adaptive Partitioning).

Fast spectroscopic imaging using extreme ultraviolet interferometry.

Extreme ultraviolet pulses as generated by high harmonic generation (HHG) are a powerful tool for both time-resolved spectroscopy and coherent diffractive imaging. However, the integration of spectroscopy and microscopy to harness the unique broadband spectra provided by HHG is hardly explored due to the challenge to decouple spectroscopic and microscopic information. Here, we present an interferometric approach to this problem that combines Fourier transform spectroscopy (FTS) with Fourier transform holography (FTH).