Studies on Long-Lived (Pentafluorosulfanyl)phenyl-Substituted Carbocations.

A variety of long-lived carbocations containing the -(pentafluorosulfanyl)phenyl and -(pentafluorosulfanyl)phenyl groups have been characterized by low-temperature NMR spectroscopy. In the case of potential nonclassical carbocations substituted with the -(pentafluorosulfanyl)phenyl substituent, deviations from linearity when the Hammett parameter (σ) is plotted versus C NMR shifts of the carbocationic center were observed. Plotting the experimentally derived C NMR shifts versus σ or σ of classical 4-phenyl-X substituted carbocations also provides a means to accurately back-calculate the σ and σ parameters of the -SF substituent.

Correction: F multiple-quantum coherence NMR spectroscopy for probing protein-ligand interactions.

[This corrects the article DOI: 10.1039/C8RA09296F.].

F multiple-quantum coherence NMR spectroscopy for probing protein-ligand interactions.

A new F NMR method is presented which can be used to detect weak protein binding of small molecules with up to mM affinity. The method capitalizes on the synthetic availability of unique SF containing compounds and the generation of five-quantum coherences (5QC). Given the high sensitivity of 5QC relaxation to exchange events ( reversible protein binding) fragments which bind to the target with weak affinity can be identified.

Pyridine-promoted dediazoniation of aryldiazonium tetrafluoroborates: Application to the synthesis of SF5-substituted phenylboronic esters and iodobenzenes.

Pyridine promotes dediazoniation of aryldiazonium tetrafluoroborates. The formed aryl radicals were trapped with B2pin2, iodine, or tetrahydrofuran to afford boronic esters, iodobenzenes and benzenes, respectively. The application to the synthesis of (pentafluorosulfanyl)phenylboronic esters, iodo(pentafluorosulfanyl)benzenes and (pentafluorosulfanyl)benzene is shown.

[Changes of right atrial myoendocrine cells during hypertension and after arterial pressure decrease].

It is well known now that atrial cardiomyocytes carry out both contractile and endocrine activities--they synthesize, accumulate in specific secretory granules and release the natriuretic peptides. The main physiological effects of natriuretic peptides are antagonistic to the renin-angiotensin-aldostrol system, but their role in the development of hypertension is still disputable. The aim of this investigation is to estimate using electron microscopy the secretory activities of atrial myoendocrine cells in rats with inherited stress-induced arterial hypertension (ISIAH stain).