Publications by authors named "G S Godbersen"
Serotonin (5-HT) plays an essential role in reward processing, however, the possibilities to investigate 5-HT action in humans during emotional stimulation are particularly limited. Here we demonstrate the feasibility of assessing reward-specific dynamics in 5-HT synthesis using functional PET (fPET), combining its molecular specificity with the high temporal resolution of blood oxygen level dependent (BOLD) fMRI. Sixteen healthy volunteers underwent simultaneous fPET/fMRI with the radioligand [C]AMT, a substrate for tryptophan hydroxylase.
View Article and Find Full Text PDFPurpose: The human brain is characterized by interacting large-scale functional networks fueled by glucose metabolism. Since former studies could not sufficiently clarify how these functional connections shape glucose metabolism, we aimed to provide a neurophysiologically-based approach.
Methods: 51 healthy volunteers underwent simultaneous PET/MRI to obtain BOLD functional connectivity and [F]FDG glucose metabolism.
Article Synopsis
- Functional PET (fPET) is a new technique for examining brain metabolism and neurotransmitter activity, typically requiring invasive blood sampling to measure arterial input function (AIF).
- This study developed a non-invasive method using cardiac IDIF from twenty healthy individuals, validating its accuracy against traditional methods through blood sampling while participants engaged in a monetary incentive delay task.
- Results showed a strong correlation between the new IDIF method and AIF, demonstrating that this non-invasive approach provides reliable quantification of brain activity changes, making fPET more accessible in clinical settings.
Article Synopsis
- - The study presents a new functional positron emission tomography (fPET) method that quantifies glucose metabolism changes without requiring invasive arterial blood sampling, which can limit the technique's use.
- - Two datasets were used to validate this method, involving participants performing different tasks while undergoing fPET scans, with strong correlations found between task-specific metabolic changes and traditional measurements.
- - The new non-invasive approach shows reliable estimates of glucose metabolism changes and enhances the usability of fPET in research and clinical environments but sacrifices the ability to measure baseline metabolism.
Purpose: Positron emission tomography (PET) provides precise molecular information on physiological processes, but its low temporal resolution is a major obstacle. Consequently, we characterized the metabolic response of the human brain to working memory performance using an optimized functional PET (fPET) framework at a temporal resolution of 3 s.
Methods: Thirty-five healthy volunteers underwent fPET with [F]FDG bolus plus constant infusion, 19 of those at a hybrid PET/MRI scanner.