Proteomic analysis of blood serum - a new approach to the search for diagnostic markers of bronchial asthma in children.

Currently, bronchial asthma (BA) is one of the most pressing medical and social problems, the molecular aspects of the formation and development of BA are insufficiently studied and the diagnosis is not perfect. Carrying out proteomic analysis of BA will not only reveal new biomarkers specific to this disease, but also bring us closer to understanding its pathogenetic mechanisms. The purpose of the study: to study the proteomic profile of blood serum of children with BA to identify proteins associated with this disease A comprehensive clinical and laboratory examination of children suffering from BA and control group patients was performed.

Determinants of COVID-19 vaccine acceptance in a high infection-rate country: a cross-sectional study in Russia.

Background: COVID-19 vaccine development is proceeding at an unprecedented pace. Once COVID-19 vaccines become widely available, it will be necessary to maximize public vaccine acceptance and coverage.

Objective: This research aimed to analyze the predictors of COVID-19 vaccine acceptance in Russia.

[Drug-induced hepato- and nephropathy].

Upon clinical and pathological analyses of the evidence obtained on drug-related lethal nephropathies (51 cases) and hepatopathies (14 cases) as well as at puncture biopsies of the livers affected by chemotherapeutic agents it was determined that the commonest variants of the disturbances were tubular nephropathies, tubular-interstitial nephritis, papillary renal necrosis, symmetric cortical renal necrosis, fulminant hepatopathies with diffuse massive necrosis of hepatocytes. For biopsies, cholestatic drug-induced hepatopathies were found most frequently. As a rule, the patients received polychemotherapy with psychotropic, cardiovascular and antidiabetic drugs, nonsteroids, antibiotics, sulfanilamides, consumed contrast diagnostic media.