Publications by authors named "G S Fossati"
Article Synopsis
- The study assessed the effectiveness and safety of Direct Selective Laser Trabeculoplasty (DSLT) in patients with open angle glaucoma and ocular hypertension.
- In a retrospective analysis of 15 eyes from 10 patients, success was achieved in 73.3% of cases, with a significant reduction in intraocular pressure (IOP) from 22.7 mmHg to 18.7 mmHg within four months.
- No major complications were reported, and DSLT's safety and effectiveness were found to be comparable to traditional Selective Laser Trabeculoplasty (SLT), suggesting it could be a viable alternative.
Article Synopsis
- HDAC6 is a key player in gene regulation and chromatin dynamics, making it an important focus in cancer research, particularly regarding its role in the stabilization of the P300 protein.* -
- Inactivating HDAC6 using an inhibitor or gene editing techniques results in increased chromatin accessibility and changes in gene expression related to cancer cell behaviors like proliferation and migration.* -
- The study suggests that instead of targeting HDAC6 directly, future cancer therapies could focus on its interaction with P300, highlighting new pathways for targeted treatment based on epigenetic changes.*
Histone deacetylase 6 (HDAC6) is increasingly recognized for its potential in targeted disease therapy. This study delves into the mechanistic and structural nuances of HDAC6 inhibition by difluoromethyl-1,3,4-oxadiazole (DFMO) derivatives, a class of non-hydroxamic inhibitors with remarkable selectivity and potency. Employing a combination of nuclear magnetic resonance (NMR) spectroscopy and liquid chromatography-mass spectrometry (LC-MS) kinetic experiments, comprehensive enzymatic characterizations, and X-ray crystallography, we dissect the intricate details of the DFMO-HDAC6 interaction dynamics.
View Article and Find Full Text PDFPurpose: We report a series of 5 cases, happened in a period of 5 months, who developed neurotrophic keratopathy (NK) following pars plana vitrectomy (PPV) and retinal endolaser for rhegmatogenous retinal detachment (RRD). In our several decennary experience of surgical center predominantly based on vitreoretinal surgery, we had rare cases of postoperative NK. These recent cases of post-surgical NK happened contextually to our change of postoperative non-steroidal anti-inflammatory drugs (NSAIDs) drops, based on Ketorolac Tromethamine 0.
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