The carboxylmethylation of cerebral membrane-bound proteins increases with age.

Recently, we have characterized a membrane-bound (mb) component of brain protein carboxylmethyltransferase II (PCMT) which effectively carboxylmethylates endogenous mb methyl-accepting proteins (MAPs). (Neurochem. Int.

Metabolism of para-aminobenzoate over time.

Potassium para-aminobenzoate incorporated into rat chow was fed ad libitum for 14 days to adult female Buffalo rats. Determination of the principal urinary metabolites, namely, p-aminobenzolyacetylester and p-aminobenzoylglucuronide, namely, p-aminobenzoylacetylester and p-aminobenzoylglucuronide, as well as p-aminobenzoylglycine and p-hydroxybenzoylglycine (hippurates), showed significantly greater amounts of the metabolites at the 14th day compared to day 1. There was no significant change in free p-aminobenzoate excretion during this interval.