Publications by authors named "G S DONATI"

Introduction: Screening for nasal carriage of Staphylococcus (S.) aureus is associated with a reduction of peritoneal dialysis (PD)-related infections, but conflicting results have questioned the benefit of this practice. This study evaluated the clinical effectiveness of the screening program for nasal carriage of S.

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Purpose: we tested whether ctDNA changes may be used to assess early response and clinical outcome in metastatic colorectal cancer (mCRC) patients undergoing front-line systemic anti-cancer therapy (SACT).

Experimental Design: 862 plasma samples were collected 4-weekly from baseline (BL) until disease progression in mCRC patients receiving front line SACT. ctDNA normalization was defined as ≥99% clearance after 1 month of therapy (Mo1) in the 3 variants with the highest allele frequency in BL ctDNA.

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The European Union (EU)-funded KitNewCare consortium aims to create and manage a comprehensive EU-wide programme focusing on sustainability in Kidney Care. Around 850 million people have chronic kidney disease (CKD) worldwide and by 2030, 6 million will need kidney replacement therapy, mainly haemodialysis. As the world population gets older, projections for the end of the century worsen.

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By inhibiting receptor-ligand interactions in sebaceous glands, antibodies may be able to treat certain skin conditions.

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Article Synopsis
  • The RNA binding protein HuR is crucial for regulating the innate immune response, and blocking it can have positive anti-inflammatory outcomes.
  • A new series of small molecules, Tanshinone Mimics (TMs), were developed to disrupt HuR-RNA binding, with furan-containing compound 5/TM11 proving to be the most effective in inhibiting this interaction.
  • Compound 5/TM11 not only enhances solubility but also selectively decreases cell proliferation in macrophages at certain doses, leading to a significant reduction in proinflammatory cytokines in response to LPS.
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