Lumefantrine (LMF) is a low-solubility antimalarial drug that cures acute, uncomplicated malaria. It exerts its pharmacological effects against erythrocytic stages of spp. and prevents malaria pathogens from producing nucleic acid and protein, thereby eliminating the parasites.
View Article and Find Full Text PDFObjective: The study aimed to assess responsiveness to the effects of acute caffeine intake after 8 weeks of Pilates intervention in healthy older adults.
Methods: Fifteen healthy older adults performed physical performance regarding daily practice, strength, and balance tests after ingestion of acute 5 mg/kg of caffeine or placebo before and after Pilates training.
Results: The caffeine intake reduced, regardless of Pilates training, the time in 10-m walk test (before placebo vs caffeine, 6.
JBI Evid Synth
January 2025
Objective: The objective of this review will be to evaluate the effect of prior aspiration versus non-aspiration during intramuscular injection on the occurrence of adverse effects in adult patients.
Introduction: Aspiration is a procedure conducted prior to the administration of intramuscular medications that aims to ensure that the needle tip is inserted in the proper place. Although aspiration is a common procedure, questions have been raised about adverse effects.
To evaluate the clinical and functional outcomes of the pharmacological block of the genicular nerves as a modality in the therapeutic arsenal for knee osteoarthritis, since it is simple, safe, and minimally invasive. The pharmacological block of the genicular nerves was performed in 20 patients with grades 3 and 4 knee osteoarthritis per the Kellgren-Lawrence classification. We assessed their clinical and functional outcomes one, three, and six months after the procedure.
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