Publications by authors named "G S Amarasinghe"
Background/aims: Buspirone shows promise in treating disorders of gut-brain interaction (DGBIs), particularly functional dyspepsia. However, findings have been mixed.
Methods: We systematically searched for prospective studies testing buspirone for any upper gastrointestinal DGBI in 4 databases (Cochrane, PubMed, Scopus, and PsycInfo).
Article Synopsis
- Jamestown Canyon virus (JCV) is a type of bunyavirus that causes neuroinvasive diseases in the U.S., but its mechanism of infection is not well understood.
- Recent research identifies low-density lipoprotein receptor related protein 1 (Lrp1) as a key factor that enables JCV and other bunyaviruses to infect cells, particularly in the nervous system.
- Experiments show that neurons lacking Lrp1 have reduced JCV infection rates, suggesting that targeting Lrp1 could lead to new antiviral treatments for diseases caused by bunyaviruses.
Article Synopsis
- The study compares the effectiveness of two quality-of-life measurement tools for children: ECOHIS-4D, focused on oral health, and EQ-5D-Y, a general tool.
- Researchers evaluated these tools based on their validity, ability to distinguish varying clinical severities, responsiveness to health changes, and correlation with dental health scores (dfs) among children.
- Findings indicate that ECOHIS-4D is significantly more effective in measuring oral health-related quality of life in children compared to EQ-5D-Y, as it showed better correlations with actual dental health outcomes.
Oropouche fever is a re-emerging global viral threat caused by infection with Oropouche orthobunyavirus (OROV). While disease is generally self-limiting, historical and recent reports of neurologic involvement highlight the importance of understanding the neuropathogenesis of OROV. In this study, we characterize viral replication kinetics in neurons and microglia derived from immortalized, primary, and induced pluripotent stem cell-derived cells, which are all permissive to infection.
View Article and Find Full Text PDFStaphylococcus aureus remains a leading global cause of bacterial infection-associated mortality and has eluded prior vaccine development efforts. S. aureus α-toxin (Hla) is an essential virulence factor in disease, impairing the T cell response to infection.
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