The impact of topical lidocaine on pain level assessment during and after vacuum-assisted closure dressing changes: a double-blind, prospective, randomized study.

Background: Vacuum-assisted closure dressing changes are frequently painful. The authors hypothesized that administering topical lidocaine into the vacuum-assisted closure sponge would decrease pain during dressing changes.

Methods: A double-blind, randomized, prospective study was performed on patients (n = 70) undergoing vacuum-assisted closure dressing changes at a single institution between October of 2003 and June of 2005.

Midazolam does not influence intravenous fentanyl-induced analgesia in healthy volunteers.

The effects of saline and intravenous midazolam (0.5, 1, and 2 mg per 70 kg) in combination with intravenous fentanyl (0.1 mg/70 kg) were examined on pain induced by a cold pressor test.

Propofol at conscious sedation doses produces mild analgesia to cold pressor-induced pain in healthy volunteers.

Study Objective: To determine whether subanesthetic doses of propofol have analgesic effects in healthy volunteers.

Design: Prospective, double-blind, placebo-controlled, randomized, crossover trial.

Setting: Human psychomotor performance laboratory within our anesthesia and critical care department.