Publications by authors named "G Rossos"
Article Synopsis
- Benzimidazole derivatives have shown various pharmacological benefits, such as anti-inflammatory and anti-cancer activities, and are significant in transition metal coordination chemistry.
- Research focused on the interactions between a particular benzimidazole compound (2-benzimidazolyl-urea) and a phospholipid bilayer to better understand drug permeability, which is crucial for effective cancer treatment.
- The study found that while both the ligand and its copper complex faced high energy barriers for membrane permeation, increasing concentrations of the ligand led to clustering and pore formation, potentially explaining its cytotoxic effects through membrane damage.
Two complexes of Zn(II) and Ni(II) ions with the urea derivative, 2-benzimidazolyl-urea (BZIMU), of formulae [ZnBZIMU)(HO)](NO) (1) and [Ni(BZIMU)(CHCHOH)](NO) (2) were synthesized and characterized by their melting point, elemental analysis, spectroscopic techniques (FTIR, UV-Vis and H-NMR), High-resolution mass spectroscopy (HRMS), molar conductivity and thermogravimetric analysis. The crystal structures of 1-2 were determined by X-ray diffraction analysis. The antiproliferative activity of 1-2 was tested in vitro against human adenocarcinoma cell lines: cervix (HeLa) and breast (MCF-7).
View Article and Find Full Text PDFStructural, photolysis and biological studies of novel mixed metal Cu(I)-Sb(III) mixed ligand complexes.
J Photochem Photobiol B
October 2016
Direct reaction of copper(I) halides with triphenylstibine (tpSb) and 2-mercapto-thiazolidine (tzdtH) in 1:1:1 molar ratio, results in the formation of the [CuX(μ2-S)-tzdtH)(tpSb)]2 (X=Cl (1), Br (2) and I (3)) complexes. The complexes have been characterized by melting point, FT-IR, UV-vis, (1)H NMR spectroscopic data and X-ray crystallography. Complexes 1-3 are di-nuclear and they are the first examples of mixed metals (CuSb), mixed ligand (thioamide, stibine and halogen) containing complexes.
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