Strategies to Stabilize Dalbavancin in Aqueous Solutions; Section-2: The Effects of 2 Hydroxypropyl-β-Cyclodextrin and Acetate Buffer with and Without Divalent Metal Ions.

The effect of 2-hydroxpropyl-β-cyclodextrin (2HPβCD) with or without divalent metal ions (Ca, Mg, and Zn) on the stability of dalbavancin in acetate buffer was investigated. Dalbavancin recovery from formulations with 2HPβCD and divalent metal ions after four weeks of storage at 5 °C and 55 °C was measured by RP-HPLC and HP-SEC; a longer-term study was carried out over six months at 5 °C, 25 °C, and 40 °C. Binding of 2HPβCD was characterized by isothermal titration calorimetry (ITC) and nuclear magnetic resonance (NMR).

Human Mesenchymal Stem Cell Promotes Burn Wound Healing by Inducing FGF and VEGF in Diabetic Rat.

<b>Background and Objective:</b> The hBM-MSCs have a high level of differentiation and proliferation in the healing process of cuts and burns. This study aimed to determine the role of hBM-MSCs in the formation of granulation tissue in diabetic burnt rats. <b>Materials and Methods:</b> Thirty rats were divided into two groups; phosphate-buffered saline (PBS) as a control group and a treatment group (BM-MSCs 2×10⁶ cells/mL).

Single intra-articular injection of human synovial membrane MSC from grade IV knee osteoarthritis patient improve cartilage repair in OA rat model.

Aim: This study aims to assess the effectiveness of therapy of human synovial membrane-derived MSCs (SM-MSC) from OA grade IV patients in treating knee OA.

Methods: SM-MSC were isolated from patients undergoing total knee replacement surgery, cultured to the fourth passage, and characterized using flow cytometry. Differentiation potential was assessed through lineage-specific staining.

The Effect of Bone Marrow Mesenchymal Stem Cells on Nestin and Gene Expression and Spatial Learning (Percent Alternation Y-Maze Test) against AlCl-Induced Alzheimer's-like Pathology in a Rat Model.

Background: Alzheimer's disease (AD) is a neurodegenerative condition characterized by gradual cognitive impairment, including loss of synapses and nerve cells involved in learning, memory, and habit formation processes. Bone Marrow Mesenchymal Stem Cells (BM-MSCs) are multipotent cells. Because of their self-renewable, differentiation, and immunomodulatory capabilities, they are commonly used to treat many disorders.