In vivo analysis of intramuscular gene transfer in human subjects studied by on-line ultrasound imaging.

The current study was designed to test the hypothesis that intramuscular (i.m.) injection of naked DNA leads to distribution of the injectate remote from the site of needle placement, a finding that might be expected to facilitate i.

Lower-extremity edema associated with gene transfer of naked DNA encoding vascular endothelial growth factor.

Background: Vascular endothelial growth factor (VEGF) promotes angiogenesis and vascular permeability. The extent to which VEGF may cause tissue edema in humans has not been established.

Objective: To evaluate patients undergoing VEGF gene transfer for evidence of lower-extremity edema.

[Ascending varicose vein phlebitis--classification and therapy].

Ascending varicophlebitis can cause pulmonary embolism by entering the deep venous system. Classification into four stages permits a differentiated therapeutic strategy: if the thrombus reaches or enters the deep venous system, immediate surgery consisting of crossectomy, resection of the saphenous vein, radical excision of all varicosed veins and ligature of insufficient perforating veins are indicated.