Publications by authors named "G Randolph"
Peer review is an essential cornerstone of scientific advancement. This process involves understanding study design, data analytics, and interpretation of the evidence. For clinicians who are performing their initial peer reviews, and even for seasoned reviewers who assess complex manuscripts, it can be helpful to have a standard approach.
View Article and Find Full Text PDFMouse and human macrophages and their roles in cardiovascular health and disease.
Nat Cardiovasc Res
December 2024
The past 15 years have witnessed a leap in understanding the life cycle, gene expression profiles, origins and functions of mouse macrophages in many tissues, including macrophages of the artery wall and heart that have critical roles in cardiovascular health. Here, we review the phenotypical and functional diversity of macrophage populations in multiple organs and discuss the roles that proliferation, survival, and recruitment and replenishment from monocytes have in maintaining macrophages in homeostasis and inflammatory states such as atherosclerosis and myocardial infarction. We also introduce emerging data that better characterize the life cycle and phenotypic profiles of human macrophages.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates management strategies for intermediate-risk papillary thyroid carcinoma (PTC) with lateral neck lymph node metastasis, focusing on comparing outcomes between lobectomy plus lateral neck dissection (LND) and total thyroidectomy plus LND.
- The research was conducted at Ito Hospital in Tokyo, Japan, involving patients who underwent surgery from 2005 to 2012, excluding those with high-risk PTCs or concurrent thyroid cancers.
- Findings from 401 patients show that overall survival rates after 5, 10, and 15 years were comparable between the two surgical options, indicating lobectomy plus LND is a viable alternative to total thyroidectomy for certain patients.
Article Synopsis
- The study investigates how 35 nuclear receptors (NRs) influence the differentiation and maintenance of key immune cells using a method called "Rainbow-CRISPR."
- It finds that receptors for retinoic acid have significant and specific roles in various immune cell types, particularly in macrophages.
- Notably, it uncovers a unique function of the retinoic acid receptor gamma (RARγ) in regulating immune cell survival and inflammasome activity, revealing its dual role in promoting health or cell death in macrophages.
Background: The 2021 Hospital Price Transparency Rule mandated hospitals to publicly disclose their service prices to improve competition and lower healthcare costs. Our aim was to characterize commercial price variation for thyroidectomy and parathyroidectomy.
Methods: We performed a national cross-sectional study of hospital price variation in 2022 and 2023 using the Turquoise Health dataset.