Publications by authors named "G Rajalakshmi Preethi"

The present study validates the impact of nickel oxide nanoparticles (NiONPs) biosynthesized from the brown seaweed Dictyota bartayresiana (DB) and its biological applications. The phytochemicals analyzed in the seaweed extract served as a reducing, capping or stabilizing agent in the formation of nanoparticles. UV visible spectrum of nickel oxide nanoparticles synthesized from DB (DB-NiONPs) represented a prominent peak at 392 nm which validates its formation.

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Mononuclear complexes [FeClL(OH)] (L = L, L) were designed and synthesized by combining FeCl with 2-(3'-Aminophenylbenzimidazole) (L) and 2-[(3'-N-Salicylidinephenyl)benzimidazole] (L) and were characterized by physico-analytical strategies. The redox properties of the complexes were disclosed by the cyclic voltammetric method. Further, the interactions of complexes with proteins were studied by performing molecular docking engaging protein models of common cancer therapeutic targets to foresee their affinity to bind to these proteins.

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Article Synopsis
  • The emergence of nanotechnology has revolutionized cancer therapy, particularly through the use of polysaccharide-based nanoparticles for drug delivery and imaging.
  • The study focuses on creating doxorubicin-loaded iron oxide nanoparticles, which improve targeted drug delivery in cancer treatment.
  • These biocompatible nanoconjugates demonstrated effectiveness in killing cancer cells in both 2-D and 3-D cultures, showing potential for reducing tumor size and burden.
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Impaction of canine is frequently encountered clinical problem in orthodontics. Canine usually erupts when two third of the root development is complete. It is considered as impacted if the root development is completed, but unaided eruption is not expected to occur.

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Iron oxide nanoparticles (IONPs) are employed as MRI contrast agents and as effective drug delivery vehicles. However, the limited solubility and biodegradability of these nanoparticles need to be improved for safer biomedical applications. In an attempt to improve the bottlenecks associated with IONPs, the current study focuses on the synthesis of folic acid conjugated, galactoxyloglucan-iron oxide nanoparticles (FAPIONPs), for the loading and controlled release of the encapsulated chemotherapeutic agent doxorubicin (DOX).

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