Publications by authors named "G Rahul Deep"
Extracellular vesicles (EVs) have emerged as novel blood-based biomarkers for various pathologies. The development of methods to enrich cell-specific EVs from biofluids has enabled us to monitor difficult-to-access organs, such as the brain, in real time without disrupting their function, thus serving as liquid biopsy. Burgeoning evidence indicates that the contents of neuron-derived EVs (NDEs) in blood reveal dynamic alterations that occur during neurodegenerative pathogenesis, including Alzheimer's disease (AD), reflecting a disease-specific molecular signature.
View Article and Find Full Text PDFGut dysbiosis contributes to multiple pathologies, yet the mechanisms of the gut microbiota-mediated influence on systemic and distant responses remain largely elusive. This study aimed to identify the role of nanosized bacterial extracellular vesicles (bEVs) in mediating allodynia, i.e.
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- Aging leads to loss of muscle mass and function, resulting in poorer health outcomes, decreased quality of life, and increased mortality risk among older adults.
- Small extracellular vesicles (sEV), which can be isolated from body fluids and contain specific biomarkers, offer a minimally invasive way to assess muscle health.
- Research on vervet monkeys showed that sEV from different age groups can reveal molecular changes related to muscle metabolism and regulation, suggesting they may serve as effective biomarkers for muscle health monitoring.
Acquisition of prostate cancer stem cells (PCSCs) manifested during androgen ablation therapy (ABT) contributes to castration-resistant prostate cancer (CRPC). However, little is known about the specific metabolites critically orchestrating this process. Here, we show that IMPA1-derived inositol enriched in PCSCs is a key metabolite crucially maintaining PCSCs for CRPC progression and ABT resistance.
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- - The study investigates the impact of hepatic growth factor (HGF) on the secretion of small extracellular vesicles (sEV) from urine-derived stem cells (USCs), focusing on two methods of HGF delivery: bolus administration and controlled release using alginate microbeads.
- - Results indicate that the group receiving HGF through controlled release from microbeads showed a significantly higher concentration of proteins and sEV compared to both the bolus and control groups after 7 days.
- - The findings suggest that using a controlled release method for HGF significantly boosts sEV secretion from USCs, which could have implications for tissue regeneration and protection.