Publications by authors named "G Rached"
Article Synopsis
- * Significant alterations in brain activity were observed in opioid users, with increased activity in the mesocorticolimbic area and decreased in the dorsolateral-prefrontal region, linked to negative emotions.
- * A follow-up after brief opioid abstention indicated changes in brain network dynamics, highlighting withdrawal signs, suggesting careful management of opioid use in chronic pain treatment.
Article Synopsis
- The study investigates the role of TRPC3, a non-selective cation channel, in regulating insulin secretion and glucose control through glucose-stimulated calcium pathways.
- Experimental methods included using pharmacological tools and Trpc3 mice to evaluate TRPC3's effect on insulin secretion in both human and animal islets, as well as its involvement in glucose uptake and calcium imaging.
- The findings suggest that TRPC3 is crucial for insulin secretion but not for glucose uptake, and its modulation may offer new therapeutic strategies for treating diabetes.
Objectives: Cancer is the second leading cause of mortality in the world, and represents an economic, social and psychological burden. Scientific studies have focused on psychosocial coping mechanisms of patients and on factors improving their quality of life. Thus, the aim of the present study is to analyze the influence that spirituality would have on the quality of life of Lebanese cancer patients and to identify whether the influence on quality of life is mediated through a decreased depression.
View Article and Find Full Text PDFGermline heterozygous mutations have been associated with high prevalence of autism spectrum disorder (ASD) and elevated rates and severity of broadly defined behavioral problems. However, limited progress has been made toward understanding whether mutation is associated with specific psychiatric co-morbidity profiles when compared to idiopathic ASD. The current study aimed to utilize a cross-measure approach to compare concurrent psychiatric characteristics across children and adolescents with mutation with (-ASD; = 38) and without ASD (-No ASD; = 23), and ASD with macrocephaly but no mutation (macro-ASD; = 25) using the Child Behavior Checklist (CBCL) and the Aberrant Behavior Checklist (ABC).
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