Publications by authors named "G Rabinowits"
Article Synopsis
- The study compares hypofractionated radiation therapy to standard fractionation in treating Merkel cell carcinoma (MCC), aiming to assess treatment outcomes and toxicity.
- A total of 29 treatment courses were reviewed from 24 patients, showing no significant differences in local or distant cancer recurrence, or overall survival between the two methods.
- The findings suggest that hypofractionated treatment is just as effective as standard fractionation, with the added benefit of requiring fewer sessions, but further research with a larger group is necessary to validate these results.
Article Synopsis
- The introduction of immune checkpoint inhibitors, like pembrolizumab, has improved treatment outcomes for head and neck squamous cell carcinoma (HNSCC), moving beyond traditional chemotherapy options.
- Combination therapies that include immunotherapy are being explored in clinical trials, and personalization based on tumor biomarkers is becoming crucial for optimizing treatment plans.
- There's a need for further clinical research and standardized guidelines, particularly concerning dental care and management of oral side effects, to enhance the effectiveness of immunotherapy in HNSCC patients.
Purpose: Coblockade of lymphocyte activation gene-3 (LAG-3) and PD-1 receptors could provide significant clinical benefit for patients with advanced melanoma. Fianlimab and cemiplimab are high-affinity, human, hinge-stabilized IgG4 monoclonal antibodies, targeting LAG-3 and PD-1, respectively. We report results from a first-in-human phase-I study of fianlimab and cemiplimab safety and efficacy in various malignancies including advanced melanoma.
View Article and Find Full Text PDFWe aimed to understand experiences with opioids and cannabis for post-treatment cancer survivors. We conducted seven focus groups among head and neck and lung cancer survivors, using standard qualitative methodology to explore themes around 1) post-treatment pain and 2) utilization, perceived benefits and perceived harms of cannabis and opioids. Survivors (N = 25) experienced addiction fears, stigma and access challenges for both products.
View Article and Find Full Text PDFThe current work-up of the primary tumor site of a head and neck squamous cell carcinoma of unknown primary is not standardized and results in several time-consuming procedures that delay treatment initiation. This article seeks to consolidate contemporary strategies used to identify the primary tumor site of an unknown primary head and neck squamous cell carcinoma and offer recommendations based on current literature review.
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