Publications by authors named "G R Villanueva"
Introduction: The COVID-19 pandemic onset had a global debilitating impact on individuals and on burgeoning careers. In 2021, the Children's Oncology Group Young Investigators Committee, Young SIOP (International Society of Paediatric Oncology) Network, and Young SIOPE (European Society for Paediatric Oncology) co-sponsored a survey to explore the impacts of the first year of the pandemic on early-career pediatric oncology professionals with respect to working practices, productivity, professional and career development, personal wellbeing, and changing childcare needs.
Methods: The survey comprised demographic, multiple-choice, and free-text questions, and was distributed via email and social media with English, French, and Spanish versions available.
Pancreatic cancer (PanCa) is one of the deadliest cancers, with limited therapeutic response. Various molecular oncogenic events, including dysregulation of ribosome biogenesis, are linked to the induction, progression, and metastasis of PanCa. Thus, the discovery of new therapies suppressing these oncogenic events and ribosome biogenesis could be a novel therapeutic approach for the prevention and treatment of PanCa.
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- - Human African trypanosomiasis is a severe neglected tropical disease that can be fatal without treatment, and the WHO has updated its treatment guidelines after a thorough review.
- - Fexinidazole is now the preferred first-line treatment for patients aged 6 years and over who weigh at least 20 kg, eliminating the need for invasive lumbar punctures for staging the disease.
- - While fexinidazole improves treatment options and reduces the risk of severe side effects from previous medicines, it remains unavailable for children who don't meet the age or weight criteria, making interim use of pentamidine necessary in some cases.
Article Synopsis
- - Charon, Pluto's largest moon, has been studied for its composition and changes caused by radiation, but previous spectral data only covered wavelengths below 2.5 μm, leaving some questions unanswered.
- - Recent observations using JWST have detected carbon dioxide (CO) and hydrogen peroxide (HO) on Charon's northern hemisphere, adding to its known chemical components like water ice and ammonia.
- - The presence of HO suggests active processes affecting the water ice surface, while spectral analysis indicates that CO is mainly found in crystalline form, likely originating from subsurface sources and other processes involving hydrocarbons and solar interactions.
Article Synopsis
- High-dose methotrexate (HDMTX) can cause acute kidney injury (AKI), making early detection crucial to prevent further damage.
- A study analyzed MTX elimination patterns as potential biomarkers for AKI in patients undergoing HDMTX treatment, utilizing ROC curves to identify significant markers.
- Results showed that early MTX elimination times are linked to AKI risk, suggesting that monitoring these patterns can help tailor patient care, including hydration and treatment adjustments.