Progressive late-onset sensorineural hearing loss and vestibular impairment with vertigo (DFNA9/COCH): longitudinal analyses in a belgian family.

Objective: To evaluate audiometric and vestibular signs and symptoms in a new DFNA9 family.

Setting: Tertiary referral centers.

Methods: A multigeneration Belgian family with late-onset progressive sensorineural hearing loss and concomitant ves-tibular impairment with an autosomal dominant pattern of inheritance underwent clinical and genetic evaluation.

Velo-cardio-facial syndrome: guidelines for diagnosis, treatment and follow-up of ent manifestations.

The Velo-Cardio-Facial Syndrome (VCFS), caused by a submicroscopic deletion in the long arm of chromosome 22, has a broad clinical spectrum of ENT manifestations including for instance velopharyngeal dysfunction, hearing problems and laryngotracheal anomalies. In the current report we present guidelines for diagnosis, treatment and follow-up of the ENT manifestations in patients with a deletion 22q11, based on our experience and the literature.

Validation of a new method of measuring esophageal acid exposure: comparison with 24-hour pH monitoring.

Recently, we developed a disposable acid exposure sensor whose in vitro response to acid below pH 4 is linearly determined by the duration of exposure and the degree of acidity. The aim of the present study was to compare the SR to simultaneous esophageal pH and duodenogastroesophageal reflux (DGER) monitoring (Bilitec) in patients investigated for presumed gastroesophageal reflux disease (GERD). Twenty-six patients (16 men, mean age 46 +/- 2 years) with symptoms suggestive of GERD underwent 24-hr ambulatory pH monitoring and SR monitoring at 5 cm proximal to the LES.

Studies on the relationship between esophageal acid exposure, mucosal lesions and heartburn using an acid exposure sensor.

Background: In vitro studies of a recently developed acid exposure sensor show that the sensor response (SR) to acid
Methods: HCl pH 1.