Mental health and post-school transitions for young people with Intellectual and Developmental Disabilities (IDD): A scoping review.

Young people with an Intellectual and Developmental Disability (IDD) often face ineffective and exclusionary post-school transition practices, leading to poor mental health in early adulthood. This scoping review aimed to map existing literature on mental health for young people with IDD during the post-school transition period including how IDD and mental health are characterised in this context and the extent to which community members with lived experience are included in the design and/or production of research. In collaboration with a co-researcher, we used the JBI framework and PRISMA guidelines in accordance with a published protocol.

Multi-institutional model to predict intensive care unit length of stay after cardiac surgery.

Objective: Intensive care unit length of stay (ICU LOS) accounts for a large percentage of inpatient cost after cardiac surgery. The Society of Thoracic Surgeons risk calculator predicts total LOS but does not discriminate between ICU and non-ICU time. We sought to develop a predictive model of prolonged ICU LOS.

A systematic review and meta-analysis on the transcriptomic signatures in alcohol use disorder.

Currently available clinical treatments on alcohol use disorder (AUD) exhibit limited efficacy and new druggable targets are required. One promising approach to discover new molecular treatment targets involves the transcriptomic profiling of brain regions within the addiction neurocircuitry, utilizing animal models and postmortem brain tissue from deceased patients with AUD. Unfortunately, such studies suffer from large heterogeneity and small sample sizes.

Integrative genomics approach identifies glial transcriptomic dysregulation and risk in the cortex of individuals with Alcohol Use Disorder.

Alcohol use disorder (AUD) is a prevalent neuropsychiatric disorder that is a major global health concern, affecting millions of people worldwide. Past molecular studies of AUD used underpowered single cell analysis or bulk homogenates of postmortem brain tissue, which obscures gene expression changes in specific cell types. Here we performed single nuclei RNA-sequencing analysis of 73 post-mortem samples from individuals with AUD (N=36, N = 248,873) and neurotypical controls (N=37, N = 210,573) in both sexes across two institutional sites.