Publications by authors named "G R Serjeant"
Article Synopsis
- A cohort study was conducted in Jamaica from 1973 to 1981, tracking 311 newborns with homozygous sickle cell disease (HbSS) to understand the prevalence and impact of aplastic crises.
- Out of the patients studied, 38% experienced clinically defined aplastic crises, typically around age 7.5, with most cases linked to parvovirus B19, although some did not show hematological changes.
- The study found that while symptoms were often nonspecific, correct diagnosis and management of these crises were generally effective, with a low recurrence rate and a few fatalities due to misdiagnosis or remote living conditions.
Objective: To document the prevalence, clinical features, haematology and outcome of acute splenic sequestration (ASS) in homozygous sickle cell disease (HbSS).
Study Design: A cohort study from birth.
Setting: The Medical Research Council Laboratories at the University of the West Indies, Kingston, Jamaica.
The objective of this study was to review the prevalence and features of the beta thalassaemia trait in Jamaican populations. Screening of 221,306 newborns over the last 46 years has given an indication of the distribution and prevalence of beta thalassaemia genes, and screening of 16,612 senior school students in Manchester parish, central Jamaica, has provided their haematological features. The prevalence of the beta thalassaemia trait predicted from double heterozygotes was 0.
View Article and Find Full Text PDFBackground: Patients with homozygous sickle cell disease (HbSS) and clinical splenomegaly by 6 months of age appeared at greater risk of invasive infections after 5 years of the Jamaican Cohort Study. We determined whether this risk remained significant over a longer study period, using a more rigorous definition of infection and examining the contribution of potential confounders.
Methods: Newborn screening of 100,000 consecutive deliveries during 1973-1981 detected 311 births with HbSS.
Article Synopsis
- The study aimed to establish ultrasound baselines for spleen size in patients with homozygous sickle cell disease (HbSS) compared to normal controls with HbAA genotype.
- Ultrasonography of spleen length showed that while it was visible in all HbAA controls, it was only seen in about 52% of HbSS scans, with HbSS patients having significantly smaller spleens.
- Findings revealed an age-related decrease in spleen size among HbSS patients, slower decline associated with genetic factors inhibiting sickling, and introduced new standards for assessing splenic health and potential issues like red cell sequestration.