Publications by authors named "G R Schade"
Objectives: To provide a contemporary statement on focal therapy (FT) for localised prostate cancer (PCa) from an international and diverse group of physicians treating localised PCa, with the aim of overcoming the limitations of previous consensus statements, which were restricted to early adopters, and to offer direction regarding the various aspects of FT application that are currently not well defined.
Materials And Methods: The FocAL therapy CONsensus (FALCON) project began with a 154-item online survey, developed following a steering committee discussion and literature search. Invitations to participate were extended to a large, diverse group of professionals experienced in PCa management.
Focal therapy (FT) is a rapidly growing field aiming to minimize the side effects of whole gland treatments in patients with localized prostate cancer and multiparametric MRI plays an important role in patient selection, treatment planning, and post-treatment monitoring. This article reviews the currently available prostate cancer FT techniques, discusses the key imaging findings that affect patient selection and treatment planning, and illustrates the spectrum of expected and abnormal post-treatment MRI findings.
View Article and Find Full Text PDFPurpose: Resilience, the ability to maintain or restore baseline function after a stressor, remains unexplored in patients with bladder cancer. Our objective was to demonstrate the feasibility of prospectively characterizing baseline resilience, related psychological resources, and frailty in patients with bladder cancer and evaluate associations with quality-of-life and mental health outcomes over time.
Materials And Methods: We enrolled patients with bladder cancer (N = 67, September 2020-July 2021) into a prospective, observational, cohort study.
Article Synopsis
- The study explores boiling histotripsy (BH) for non-invasive kidney tumor ablation, focusing on different BH dose metrics in porcine and canine kidney models.
- Various pulsing protocols were tested to assess lesion formation, revealing that in vivo kidney tissue required lower BH doses compared to ex vivo tissue for similar damage.
- Results indicated tissue stiffness and damage differed between kidney compartments, with the renal cortex needing fewer pulses for effective treatment, while the medulla and renal sinus showed higher resistance to BH dosing.
Article Synopsis
- Small cell bladder cancer (SCBC) is a rare and aggressive type of cancer, prompting a study to compare outcomes of two treatment methods: cystectomy with neoadjuvant chemotherapy (NAC) and concurrent chemoradiotherapy (CCRT).
- The study examined data from an institutional database and SEER-Medicare, identifying 53 and 1166 patients, respectively, to evaluate overall survival (OS) and found that NAC followed by cystectomy resulted in a median OS of around 45-46 months compared to lower OS of 23-26 months with CCRT.
- Although NAC + cystectomy correlated with a potential 30% reduction in mortality compared to CCRT, results were not statistically significant, highlighting