Machine learning based quantitative pain assessment for the perioperative period.

This study developed and evaluated a model for assessing pain during the surgical period using photoplethysmogram data from 242 patients. Pain levels were measured at 2 min intervals using a numerical rating scale or clinical criteria: preoperative, before and after intubation, before and after skin incision, and postoperative. Key features from the photoplethysmography waveform were extracted to build XGBoost-based models for intraoperative and postoperative pain assessment.

3D active-matrix multimodal sensor arrays for independent detection of pressure and temperature.

Pressure and temperature sensing simultaneously and independently is crucial for creating electronic skin that replicates complex sensory functions of human skin. Thin-film transistor (TFT) arrays with sensors have enabled cross-talk-free spatial sensing. However, the thermal dependence of charge transport in semiconductors has resulted in interference between thermal and pressure stimuli.

Phase Engineering of SnSe (X = 1,2) Microstructures for High-Performance NO Chemiresistive Room-Temperature Sensor Systems: Toward Highly Reliable and Robust Detection Properties under Humidity and Interfering Gas Conditions.

Two-dimensional SnSe (X = 1, 2) has emerged as a promising candidate for a NO chemiresistive sensor due to a remarkable affinity to NO gas adsorption. Although their gas sensing mechanism primarily relies on direct charge transfer, the underlying mechanisms of SnSe and SnSe remain unclear, despite various reported successes in phase engineering of SnSe. Here, we investigate phase engineering of SnSe in a hydrothermal route via 1-dodecanethiol (1-DDT), which served as a phase stabilizer, and comprehensively demonstrate phase-dependent NO detection properties.

Urolithin A Protects Hepatocytes from Palmitic Acid-Induced ER Stress by Regulating Calcium Homeostasis in the MAM.

An ellagitannin-derived metabolite, Urolithin A (UA), has emerged as a potential therapeutic agent for metabolic disorders due to its antioxidant, anti-inflammatory, and mitochondrial function-improving properties, but its efficacy in protecting against ER stress remains underexplored. The endoplasmic reticulum (ER) is a cellular organelle involved in protein folding, lipid synthesis, and calcium regulation. Perturbations in these functions can lead to ER stress, which contributes to the development and progression of metabolic disorders such as metabolic-associated fatty liver disease (MAFLD).

Elevated IL-17A-Secreting Regulatory T Cells in Sinonasal Tissues of Chronic Rhinosinusitis with Nasal Polyps.

During nasal polyp (NP) development, activated T cells differentiate into T helper (Th) 1, Th2, and Th17 cells. Additionally, regulatory T cells (Tregs) that have an immune suppressive function are involved in the pathophysiology of chronic rhinosinusitis (CRS) with NP (CRSwNP). Tregs can act as effector cells that produce inflammatory cytokines, such as interleukin (IL)-17A.