Publications by authors named "G R Rhodes"
Article Synopsis
- * Current tests for measuring Lp(a) often assess total apo(a), which may not accurately reflect Lp(a) levels or the effects of new treatments.
- * A new immunoassay developed for measuring Lp(a) particles showed better accuracy, indicating that muvalaplin's Lp(a)-lowering effects were previously underestimated by commercial tests, while lepodisiran's effects were consistent across both methods.
Article Synopsis
- A recent study showed that muvalaplin effectively inhibits the formation of lipoprotein(a), reducing its levels significantly, with reductions up to 85.8% observed in higher dosages over a 12-week period for those at high cardiovascular risk.
- * The phase 2 trial involved 233 participants with elevated lipoprotein(a) and conditions like atherosclerosis and diabetes, testing different dosages of muvalaplin against a placebo.
- * Results indicated substantial decreases in lipoprotein(a) concentrations and generally demonstrated that muvalaplin is well tolerated, but the long-term effects on high-risk populations require further investigation.
Background: Whether revascularisation (REV) improves outcomes in patients with three-vessel coronary artery disease (3V-CAD) is uncertain.
Aims: Our objective was to evaluate outcomes with REV (percutaneous coronary intervention [PCI] or coronary artery bypass graft surgery [CABG]) versus medical therapy in patients with 3V-CAD.
Methods: ISCHEMIA participants with 3V-CAD on coronary computed tomography angiography without prior CABG were included.
We describe the development, testing and specificity of a modified oligonucleotide probe for the specific detection of Mycobacterium avium subsp. paratuberculosis (MAP) in culture and in infected tissue using fluorescent in situ hybridisation and confocal microscopy. The detection of MAP in both animal and human tissue using our modified probe allows for a more rapid diagnosis of MAP infection compared to the more often applied detection methods of culture and PCR and has the potential for quantification of cellular abundance.
View Article and Find Full Text PDF