Publications by authors named "G R Meeks"
Aging is associated with genome-wide changes in DNA methylation in humans, facilitating the development of epigenetic age prediction models. However, most of these models have been trained primarily on European-ancestry individuals, and none account for the impact of methylation quantitative trait loci (meQTL). To address these gaps, we analyzed the relationships between age, genotype, and CpG methylation in 3 understudied populations: central African Baka (n = 35), southern African ‡Khomani San (n = 52), and southern African Himba (n = 51).
View Article and Find Full Text PDFA multinational outbreak of nosocomial fusarium meningitis occurred among immunocompetent patients who had undergone surgery with epidural anesthesia in Mexico. The pathogen involved had a high predilection for the brain stem and vertebrobasilar arterial system and was associated with high mortality from vessel injury. Effective treatment options remain limited; in vitro susceptibility testing of the organism suggested that it is resistant to all currently approved antifungal medications in the United States.
View Article and Find Full Text PDFArticle Synopsis
- Resource managers often believe increasing genetic diversity is crucial for preventing extinction in small populations, but this might not always be necessary.
- A study on the peregrine falcon showed that nonmigratory and island populations had lower genomic diversity and higher inbreeding, yet inbreeding might not be a significant threat for all populations.
- The findings suggest that factors like population decline history may be more important to consider than just genetic diversity when making conservation decisions.