Publications by authors named "G R Mair"
Article Synopsis
- Estimating the age of acute ischemic brain lesions is crucial for managing strokes effectively, and the best current method involves measuring the Relative Intensity of brain lesions using non-contrast CT scans.
- A new convolutional neural network-based model (CNN-R) was developed to improve lesion age estimation, trained on actual time from onset to scan and validated with extensive external datasets.
- The CNN-R model demonstrated significantly better accuracy in predicting lesion age and understanding early lesion growth compared to traditional methods, making it a valuable tool for stroke diagnosis.
Background: CT is commonly used to image patients with ischaemic stroke but radiologist interpretation may be delayed. Machine learning techniques can provide rapid automated CT assessment but are usually developed from annotated images which necessarily limits the size and representation of development data sets. We aimed to develop a deep learning (DL) method using CT brain scans that were labelled but not annotated for the presence of ischaemic lesions.
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- Hemorrhagic transformation is a serious complication of intravenous thrombolysis (IVT) in acute ischemic stroke, and this study aimed to understand its impact on clinical outcomes by evaluating different hemorrhage patterns.
- The research analyzed data from the Enhanced Control of Hypertension and Thrombolysis Stroke Study and defined symptomatic intracerebral hemorrhage (sICH) and asymptomatic intracerebral hemorrhage (aICH) based on established criteria, examining their associations with patient outcomes.
- Results showed that 17.8% of participants experienced intracranial hemorrhage, with sICH significantly linked to worse outcomes, including death and major disability, while aICH also posed risks, though to a lesser extent.
Unlabelled: parasites, the causative agents of malaria, undergo closed mitosis without breakdown of the nuclear envelope. Unlike closed mitosis in yeast, parasites undergo multiple rounds of asynchronous nuclear divisions in a shared cytoplasm. This results in a multinucleated organism prior to the formation of daughter cells within an infected red blood cell.
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- - The ATTEST-2 trial evaluated if tenecteplase, a newer thrombolytic agent, is at least as effective as the standard alteplase within 4.5 hours of an acute ischaemic stroke by comparing outcomes like the modified Rankin Scale (mRS) at 90 days post-treatment.
- - Conducted across 39 UK stroke centers, the study randomly assigned 1,777 eligible stroke patients to receive either tenecteplase or alteplase, focusing on their recovery outcomes and safety, including complications such as bleeding.
- - Results showed that tenecteplase was non-inferior to alteplase regarding the distribution of mRS scores, but it did not