Are higher doses of nicotine replacement more effective for smoking cessation?

This study determined whether higher dose nicotine patches are more efficacious than lower dose patches among heavy smokers. A randomized double-blind study compared 0, 21, 35, and 42 mg/day of a 24-h patch in 1039 smokers (> or = 30 cigarettes/day) at 12 clinical sites in the USA and one in Australia. Daily patches were used for 6 weeks followed by tapering over the next 10 weeks.

Corporate healthcare costs and smoke-free environments.

Results from two studies were combined to assess potential market impact for programs to reduce health risks, as well as to define how small businesses can better control their healthcare operating expenses, widen their profit margins, and increase their productivity. The most effective solutions resulted from partnerships among the medical, business, and patient communities for the joint implementation of intensive smoking-cessation programs. In the first study, the chief executive officers of 1,100 small businesses in the Chicago area were polled regarding their opinions on healthcare costs.

Passive smoking: the medical and economic issues.

Since the late 1970s, the dangers associated with passive (involuntary) smoking have been widely debated. While research throughout the world has produced findings showing sidestream smoke to be harmful and possibly deadly to nonsmokers, an equal number of studies have indicated that the harms have been overstated or misclassified or that they are nonexistent. Those debates have culminated in a report sponsored by the Environmental Protection Agency and other federal agencies.

Serum creatine kinase and lactate dehydrogenase changes following an eighty kilometer race. Relationship to lipid peroxidation.

Pre and post race serum malondialdehyde (MDA), creatine kinase (CK) and lactate dehydrogenase (LDH) levels were studied in runners following an 80 km (50 mile) race. MDA is an indicator of lipid peroxidation. Subjects averaged 47.

Physiological Profiles of Two Champion Ultramarathoners.

In brief: Two ultramarathon world-record holders were studied immediately after a 50-mile race and in a laboratory under controlled conditions. Blood samples were obtained before and after running and were analyzed for lactate, glucose, glycerol, and free fatty acid. Muscle biopsies were also performed and analyzed for glycogen, enzyme activity, and fiber type.