Lipid Nanoparticles (LNPs) recently emerged as an invaluable RNA delivery platform. With many LNP-based therapeutics in the pre-clinical and clinical pipelines, there is extensive research dedicated to improving LNPs. These efforts focus mainly on the tolerability and transfectability of new ionizable lipids and RNAs, or modulating LNPs biodistribution with active targeting strategies.
View Article and Find Full Text PDFBackground: The ACR in 2021 and the EULAR in 2022 published recommendations for management of ANCA-associated vasculitis. Given the differences in the demographic, clinical profiles, and the socio-economic realities between various countries, there is a need for development of guidelines for the management of AAV for less economically developed regions of the world.
Methods: These guidelines were made following the GRADE methodology.
Although poultry is the largest meat by volume produced in Fiji, there has not been any established study, nor application of the anaerobic digestion (AD) of poultry manure (PM) in the country. This paper aims to determine the techno-economic feasibility of the AD of PM to power a poultry farm in Fiji. A pilot scale study was first conducted with mono-digestion batches of poultry manure, and co-digestions with kitchen waste (KW) and newspaper waste (NPW).
View Article and Find Full Text PDFRare-earth elements (REEs) play a crucial role in state-of-the-art technologies and sustainable energy generation. However, conventional production methods of REE often instigate detrimental impacts on environment. Hence, the development of efficient and sustainable hydrometallurgical methods for REE recovery from complex solution has become a crucial research focus.
View Article and Find Full Text PDFPurpose: Retinoblastoma, a curable childhood cancer, has been identified as a tracer cancer in the WHO Global Initiative for Childhood Cancer. To document the outcomes of children with retinoblastoma in South Africa, treated as per the first prospective standard national treatment guidelines for childhood cancer in South Africa.
Patients And Methods: All children diagnosed with retinoblastoma between 2012 and 2016 in five South African pediatric oncology units were treated with a standard treatment on the basis of the International Society of Pediatric Oncology-Pediatric Oncology in Developing Countries guidelines for high-income settings.