Publications by authors named "G R Caputo"

Background: Infections associated with implant-based breast reconstructive surgery are challenging for both patients and surgeons, often implying high recurrence rate, long treatments (both medical and surgical management), multiple invasive procedures, and delay of the end-result and, in some cases, even reconstruction failure. Early diagnosis is crucial but not always easy to achieve. Various treatment options are available and have been described in literature, with no clear winning strategy.

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Purpose: To describe the incidence of CME in re-DMEK procedures and identify the associated risk factors.

Methods: Retrospective case series of 88 patients who underwent re-DMEK surgeries from January 2013 to October 2023. Surgical results were analyzed based on the cause of corneal decompensation, associated ophthalmologic factors, occurrence of CME after primary DMEK surgery, incidence of CME after re-DMEK, time interval between surgery and onset of CME, and management and outcomes of CME.

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Retinopathy of prematurity (ROP, ORPHA: 90050) is the main cause of visual impairment in preterm infants and the leading preventable cause of childhood blindness in high- and middle-income countries. However, severe stages of the disease remain rare. While screening recommendations for the disease are well-established in France, management of ROP requiring treatment is less standardized, especially since new therapeutic options have been approval on this indication.

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Article Synopsis
  • Ionic liquids (ILs), especially fatty acid-based ILs (FAILs), show promise in antibiotic formulations due to their ability to permeabilize lipid bilayers with low cytotoxicity to human cells.
  • The study tested different FAILs, specifically tetramethylguanidinium (TMG) or choline combined with octanoate or decanoate, to analyze their effects on lipid bilayers and bacteria.
  • Results indicated that while octanoate-based FAILs displayed low activity, decanoate-based FAILs successfully permeabilized cell membranes and demonstrated better antibacterial activity, suggesting a non-micelle based mechanism of action.
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