Publications by authors named "G R Bushee"
Article Synopsis
- Pediatric urinary tract infections (UTIs) require timely diagnosis and proper treatment to minimize health issues, with a study showing inconsistent management practices among 13,000 children regarding antibiotic choices.
- A local team recommended cephalexin as the preferred first-line treatment in 2019 due to its effectiveness, low cost, and ease of use, aiming to boost its prescription rates from 34% to 75% within six months.
- After implementing standardized care pathways and provider education, the prescribing rate for cephalexin increased to 66%, demonstrating improved adherence to guidelines without affecting the rate of return visits for UTIs.
Article Synopsis
- This study analyzed 2,685 children aged 2 months to 18 years who were treated with oral antibiotics for confirmed urinary tract infections (UTIs).
- The main outcomes measured were hospital re-visits within 30 days and changes to antibiotic treatment within 14 days, with cefdinir showing lower modification rates compared to cephalexin and sulfamethoxazole-trimethoprim.
- Cephalexin was suggested as a preferred first-line treatment due to its lower side effects and effective performance in treating uncomplicated pediatric UTIs.
Background: Our internal infant sepsis evaluation clinical practice guideline recommends infants with negative culture results who are undergoing sepsis evaluation receive antibiotics until culture results are negative for a maximum of 36 hours. The aims of our project were to decrease the percentage of patients who received >30 hours of administered antibiotic doses (recognizing effective concentrations last until hour 36) and increase 36-hour phrase documentation by using clinical decision support tools.
Methods: We used quality improvement methodology to study infants aged ≤60 days with negative culture results.
Extended Infusion of Beta-Lactams Is Associated With Improved Outcomes in Pediatric Patients.
J Pediatr Pharmacol Ther
February 2021
Article Synopsis
- - The study aimed to compare the clinical outcomes of extended versus standard infusions of beta-lactam antibiotics in hospitalized pediatric patients, focusing on drugs like cefepime, piperacillin-tazobactam, and meropenem.
- - A total of 551 patients were reviewed, and overall, the clinical outcomes were similar for both infusion methods; however, some subgroups showed significant differences.
- - Critical care patients receiving extended infusions had lower mortality rates, and bone marrow transplant patients experienced fewer readmissions, suggesting potential benefits in these specific populations.