Publications by authors named "G R A Froemming"
(1) The complexity of diabetes and diabetic wound healing remains a therapeutic challenge because proper and systematic wound care and management are essential to prevent chronic microbial infection and mechanical damage to the skin. , locally known as 'Kacip Fatimah', is an herb that has been previously reported to possess anti-inflammatory, analgesic, antinociceptive and antipyretic properties. The current study aims to assess the antioxidant and fibroblast cell migration activities of the fractions eluded from the dichloromethane extract of leaves.
View Article and Find Full Text PDFIntroduction: Thymoquinone (TQ) is one of the bioactive compounds in Nigella sativa (NS). Also known as black seeds/cumin, it has been postulated to possess anti-atherogenic properties. However, research on the effects of NS oil (NSO) and TQ on atherogenesis remain scarce.
View Article and Find Full Text PDFStreptozotocin (STZ) is a broad-spectrum antibiotic that is toxic to the insulin-producing beta cells of the pancreatic islets. STZ is currently used clinically for the treatment of metastatic islet cell carcinoma of the pancreas and the induction of diabetes mellitus (DM) in rodents. So far, there has been no previous research to show that STZ injection in rodents causes insulin resistance in type 2 diabetes mellitus (T2DM).
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- - Diabetic foot ulcers are a major complication of poorly managed diabetes, leading to high rates of hospital admissions and non-traumatic amputations, primarily due to factors like poor glycemic control, neuropathy, and vascular issues.
- - Antioxidants may help improve the healing of diabetic wounds by addressing redox imbalances and oxidative stress, while matrix metalloproteinases (MMPs) are essential in various stages of the wound healing process.
- - This study focuses on isolating bioactive components from a specific extract and assessing their antioxidant and wound healing potential through various experiments, including tests on diabetic rats and human cell lines.
Low mineralization activity by human osteoblast cells (HOBs) indicates abnormal bone remodeling that potentially leads to osteoporosis. Oxidation, the most prominent form of high-density lipoprotein (HDL) modification, is suggested to affect bone mineralization through the inflammatory pathway. Adiponectin, which possesses anti-inflammatory activity, is postulated to have the ability to suppress the detrimental effects of oxidized HDL (oxHDL).
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