Impaired reprogramming of the autophagy flux in maturing dendritic cells from crohn disease patients with core autophagy gene-related polymorphisms.

Crohn disease (CD) is an inflammatory bowel disease whose pathogenesis involves inappropriate immune responses toward gut microbiota on genetically predisposed backgrounds. Notably, CD is associated with single-nucleotide polymorphisms affecting several genes involved in macroautophagy/autophagy, the catabolic process that ensures the degradation and recycling of cytosolic components and microorganisms. In a clinical translation perspective, monitoring the autophagic activity of CD patients will require some knowledge on the intrinsic functional status of autophagy.

Comparison of Level and Graded Treadmill Tests to Evaluate Endurance Mountain Runners.

Mountain endurance running has increased in popularity in recent years. Thus the aim of the present study was to determine if maximal oxygen uptake (VO2max) and energy cost of running (Cr) measured during level and uphill running are associated. Ten high level male endurance mountain runners performed three maximal oxygen uptake tests at three slope conditions (0, 12.

[Cannabis and myocardial infarction without angiographic stenosis in young patient: guilty or not guilty? A case report].

Cannabis is the most consumed drug in France, particularly in young adults. Few reports have suggested a causal role of cannabis in the development of cardiovascular events. We describe one case of 26-year-old man, cannabis and tobacco smoker, admitted with recurrent ischemic stroke cause by post-myocardial infarction left ventricular thrombus.

[Acute heart disease in search and rescue helicopter missions, from French Navy. A retrospective study from 2000 to 2007].

Background: Search and rescue helicopters from the French navy conduct ambulance and search and rescue missions near the western coast of the French Britain. The team on board includes military doctor and paramedic. Operations in this area are challenging due to long distances and severe weather conditions.