Strategically constructed hybrid bulk-heterojunction for efficient flexible self-powered infrared photodetectors with a carbon electrode.

The construction of an admirable hybrid bulk-heterojunction (HBH) can benefit the performance of optoelectronic devices through efficient charge separation and transportation. However, the present HBH structure still suffers from complicated layer-by-layer ligand exchanges during device fabrication. In this work, we apply a liquid phase exchange strategy in mixed colloidal hybrids composed of quantum dots (QDs) and nanotetrapods (NTs) and construct low-cost flexible self-powered infrared photodetectors with a carbon electrode.

Feasibility of real-time fMRI neurofeedback for rehabilitation of reading deficits in aphasia.

Background: Reading impairments, a common consequence of stroke-induced aphasia, significantly hinder life participation, affecting both functional and leisure activities. Traditional post-stroke rehabilitation strategies often show limited generalization beyond trained materials, underscoring the need for novel interventions targeting the underlying neural mechanisms.

Method: This study investigates the feasibility and potential effectiveness of real-time functional magnetic resonance imaging (fMRI) neurofeedback (NFB) intervention for reading deficits associated with stroke and aphasia.

ET-PROTACs: modeling ternary complex interactions using cross-modal learning and ternary attention for accurate PROTAC-induced degradation prediction.

Motivation: Accurately predicting the degradation capabilities of proteolysis-targeting chimeras (PROTACs) for given target proteins and E3 ligases is important for PROTAC design. The distinctive ternary structure of PROTACs presents a challenge to traditional drug-target interaction prediction methods, necessitating more innovative approaches. While current state-of-the-art (SOTA) methods using graph neural networks (GNNs) can discern the molecular structure of PROTACs and proteins, thus enabling the efficient prediction of PROTACs' degradation capabilities, they rely heavily on limited crystal structure data of the POI-PROTAC-E3 ternary complex.

A SARS-CoV-2 EG.5 mRNA vaccine induces a broad-spectrum immune response in mice.

The emerging of emergent SARS-CoV-2 subvariants has reduced the protective efficacy of COVID-19 vaccines. Therefore, novel COVID-19 vaccines targeting these emergent variants are needed. We designed and prepared CoV072, an mRNA-based vaccine against SARS-CoV-2 Omicron (EG.

A case of massive hemoptysis caused by immunoglobulin G4-related respiratory disease in adults: case report and review of literature.

Immunoglobulin G4-related disease (IgG4-RD) is an immune-mediated chronic fibro-inflammatory condition, that can involve multiple systems. Immunoglobulin G4-related respiratory disease (IgG4-RRD) is relatively rare, with non-specific clinical symptoms. Hemoptysis is a rare clinical symptom of IgG4-RRD, and cases of massive hemoptysis in adults have not been reported.