Microfluidic-Enabled Self-Directed Hydrogel Microspheres for Multiplexed MicroRNA Assays.

Multiplexed microRNA (miRNA) detection has proven valuable in disease diagnosis; yet, the development of advanced tools for their analysis remains a subject of broad interest. Here, we propose a novel single-particle method for multiplexed miRNA detection using self-directed hydrogel microspheres, which feature supersegmented compartments for loading analyte probes and an air-encapsulated region that grants the microsphere a unique preferred posture in aqueous solutions. By exploiting microfluidic technology, we can widely adjust the size of the microspheres and the number of compartments can be widely adjusted.

Cerebral perfusion correlates with amyloid deposition in patients with mild cognitive impairment due to Alzheimer's disease.

Background: Changes in cerebral blood flow (CBF) may contribute to the initial stages of the pathophysiological process in patients with Alzheimer's disease (AD). Hypoperfusion has been observed in several brain regions in patients with mild cognitive impairment (MCI). However, the clinical significance of CBF changes in the early stages of AD is currently unclear.

AgGaS and Derivatives: Design, Synthesis, and Optical Properties.

Silver gallium sulfide (AgGaS) is a ternary ABX-type semiconductor featuring a direct bandgap and high chemical stability. Structurally resembling diamond, AgGaS has gained considerable attention as a highly promising material for nonlinear optical applications such as second harmonic generation and optical parametric oscillation. In attempts to expand the research scope, on the one hand, AgGaS-derived bulk materials with similar diamond-like configurations have been investigated for the enhancement of nonlinear optics performance, especially the improvement of laser-induced damage thresholds and/or nonlinear coefficients; on the other hand, nanoscale AgGaS and its derivatives have been synthesized with sizes as low as the exciton Bohr radius for the realization of potential applications in the fields of optoelectronics and lighting.

Defective boron nitride aerogels by salt template synthesis: A green adsorbent for tetracycline removal.

Hexagonal boron nitride (h-BN) exhibits unique application potential in water purification due to its large specific surface area, high porosity, and chemical inertness. Designing adsorbents with highly active adsorption sites is one effective method to improve their adsorption capacities. In this study, porous h-BN aerogels containing multiple defect types (DP-BN) were synthesized by using salt templates.

Organic Luminescent Cocrystals Based on Benzotriazole Derivatives: Synthesis, Characterization, Crystal Structure and Fluorescence Behavior.

Organic cocrystals have garnered significant research attention owing to their distinctive properties and promising applications. However, challenges in molecular structure design and control of intermolecular interactions continue to impede further advancements. In this study, two novel cocrystals were successfully formed from a series of synthesized benzotriazole derivatives.